– Faculty appointment
– Active musculoskeletal researcher
– Intent to participate in MRC programs and/or use Core services
The MRC research community has more than 80 members (PIs) who have over 60 million dollars of annual research support (direct costs).
Bone & Mineral Diseases
- Email: email@example.com
Focus: the role of the Leucine rich Repeat with a Pyrin domain 3 (NLRP3) inflammasome in bone.
- Email: firstname.lastname@example.org
Focus: cartilage tissue, both articular and growth plate cartilage.
Saint Louis University – Orthopaedic Surgery
Focus: the role of bone morphogenetic protein two (BMP2) on skeletal development and bone quality.
- Email: email@example.com
Focus: Regulation of growth and patterning. Our recent preliminary data in Drosophila has indicated that a poorly understood nuclear envelope protein, Nemp, is required for fertility and muscle stem cells. We are interested in determining if this is true for mammals. We have generated Nemp1 mutant mouse, and our recent preliminary data suggest a role in the muscle and skeleton. In addition, we study Fat4, a large cadherin. Mutations in Fat4 are associated with Van maldergem syndrome, which is characterized by a range of defects, including skeletal defects. We have generated targeted mutations in Fat4 in mice with CRISPR, and want to determine if there are defects in muscle and skeleton.
- Email: firstname.lastname@example.org
Focus: preclinical multimodal imaging technologies for biomarker discovery in orthopedic diseases
University of Missouri – Pathology
- Email: email@example.com
Focus: the integrative biology and evolution of vertebrate “locomotor tissues” including not only bones and muscles but also feathers and wing membranes.
- Email: firstname.lastname@example.org
Focus: (1) fatty acid and lipoprotein metabolism leading to the discovery of significant sexual dimorphism in the regulation of lipid metabolism and (2) muscle protein metabolism with the goal to elucidate the influences of sex hormones, male/female genotype and fibre composition on the muscle anabolic response to feeding and exercise.
- Email: email@example.com
Focus: Understanding the changes to paraspinal musculature in adult spinal deformity and degenerative diseases.
- Email: firstname.lastname@example.org
Focus: Brain-Computer Interfacing using intracalvarial electrodes.
Bone & Mineral Diseases
- Email: email@example.com
Focus: the molecular genetics of metabolic bone diseases and skeletal dysplasias, with special emphasis on the patient population at the Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St. Louis.
Bone & Mineral Diseases
- Email: firstname.lastname@example.org
Focus: the pharmacogenetics of osteoporosis, with emphasis on estrogen metabolic pathways, on the effects of bisphosphonates and other pharmacologic agents in osteoporosis, and on the effects of diabetes on bone health.
- Email: email@example.com
Focus: young adult hip disorders and pediatric sports medicine.
Cell Biology and Physiology
- Email: firstname.lastname@example.org
Focus: Role of ion channels in skeletal muscle fatigue and damage, and in skeletal deformation.
- Email: email@example.com
Focus: the mechanisms by which growth factors modulate skeletal fracture repair.
- Email: firstname.lastname@example.org
Focus: the impact of chemerin modulation in mouse models of prostate cancer.
Internal Medicine Division of Rheumatology
- Email: email@example.com
Focus: Design and deployment of practical and safe solutions for unmet medical needs. I have extensive research experiences in developing molecular diagnosis and nano-based drug/gene delivery strategies for inflammatory diseases, including autoimmune arthritis, cardiovascular diseases, kidney diseases, and cancer.
- Email: firstname.lastname@example.org
Focus: cartilage regeneration, hip dysplasia, hip impingement, biomarkers, tissue engineering, stem cells, osteoarthritis.
- Email: Kamlesh.email@example.com
Focus: Investigation of muscle histology in patients with cleft lip and palate.
- Email: firstname.lastname@example.org
Focus: The importance of FGFR signaling to bone development and homeostasis using mouse as a model system.
- Email: email@example.com
Focus: role of proteases in immunity and autoimmunity.
Biochemistry and Child Health | Univ. of Missouri
- Email: PhillipsCL@missouri.edu
Focus: The molecular/biochemical pathogenesis of osteogenesis imperfecta (OI) in mineralized and non-mineralized tissues, with a recent focus to develop alternative pharmacologic and therapeutic strategies to enhance muscle and bone quality and biomechanical integrity.
- Email: firstname.lastname@example.org
Focus: PTH signaling. PTH1R. Calcium and phosphorus homeostasis.
- Email: email@example.com
Focus: early molecular mechanisms that orchestrate changes in knee joint after injury and lead to the development of osteoarthritis.
- Email: firstname.lastname@example.org
Focus: Spinal cord injury, cervical myelopathy, electrical stimulation – peripheral nerve regeneration, electrical stimulation – bony fusion, peripheral neuroprosthetics
Biomedical Engineering (Saint Louis University)
- Email: email@example.com
Focus: Understanding the biomechanics of musculoskeletal soft tissue using methods ranging from preclinical models to wearable sensors in people.
Surgery, Division of Plastic and Reconstructive Surgery
- Email: firstname.lastname@example.org
Focus: Advancements in the fields of plastic and reconstructive surgery as whole, and specifically vascularized composite allotransplantation, tissue engineering, vascular perfusion assessment, breast reconstruction, and lymphedema. As such, the role of musculoskeletal tissue has a critical role in understanding the pathology, injury, or regeneration to achieve advances in these areas.
- Email: email@example.com
Focus: studying the intersection of ion channel mechanobiology and metabolism with a focus on cardiometabolic disease
Bone & Mineral Diseases
- Email: firstname.lastname@example.org
Focus: synthesis of concepts from cell biology, physiology, and bioengineering to study the relationships between the nervous system and the skeleton. We have a directed interest in understanding how neural signals contribute to skeletal homeostasis, and how perturbations to this system contribute to bone loss, impaired healing, and changes in metabolism.
- Email: email@example.com
Focus: imaging and fluid-based biomarkers of disease to characterize therapy benefits for pain and dysfunction.
- Email: firstname.lastname@example.org
Focus: the biological and mechanical factors that regulate tendon development, injury, and repair, as a basis to develop new therapeutic approaches to improve tendon healing.
- Email: email@example.com
Focus: molecularly targeted small molecule and multi-functional macromolecular bio-conjugates for nuclear and optical imaging of cancer and cardiovascular diseases. We are currently developing multi-modal imaging platforms for studying bone marrow related malignancies such as multiple myeloma.
- Email: firstname.lastname@example.org
Focus: facial reconstruction, facial nerve disorders, facial paralysis, facial clefts, cleft lip, cleft palate, ear reconstruction, microtia, reconstruction of obstetrical brachial plexus injuries, microsurgical procedures in children and adults.
- Email: email@example.com
Focus: the cellular and molecular genetic mechanisms underlying vertebrate gastrulation, a crucial period of embryogenesis during which the germ layers are formed and then shaped into the vertebrate body plan with organ rudiments.
Cell Biology & Physiology
- Email: firstname.lastname@example.org
Focus: the impact of aging on the tumor microenvironment.
Focus: (1) understanding the effect of disease mechanisms on the structure-function relationships of skeletal tissues and (2) developing of translatable therapeutic and regenerative strategies for these diseases. The investigation of these scientific questions includes the application of finite element analyses, multiscale tissue mechanics, the functional imaging of skeletal tissues, and development of nanostructures and nanomaterials for regenerative medicine with in vitro and in vivo biological systems.
Pathology & Immunology
- Email: email@example.com
- Email: firstname.lastname@example.org
Focus: 1) the sensory-motor factors underlying musculoskeletal pain conditions, and 2) how these factors interact with activity demand and psychsocial factors to increase risk for, or contribute to an existing musuloskeleletal pain condition.
- Email: email@example.com
Focus: the initiation, progression and relapse mechanisms of osteosarcoma.
University of Nebraska-Lincoln
- Email: firstname.lastname@example.org
Focus: establish robust animal models of chronic low back pain
University of Nebraska-Lincoln
- Email: email@example.com
Focus: using various chemistry, pharmaceutical, and nanomedicine tools to address major problems in the diagnosis and treatment of musculoskeletal, inflammatory and craniofacial/dental diseases
- Email: firstname.lastname@example.org
Focus: the role of protein aggregation in hereditary myopathies and motor neuron disease
- Email: email@example.com
Focus: the molecular basis of bone metastasis, with a particular interest in the critical roles of osteoclast and osteoblast beta 3 integrin signaling pathway genes, the viral oncogene, Tax, and the bone marrow homing molecules, VLA-4, CXCR4 and G-CSF in the process of bone metastasis and multiple myeloma bone marrow colonization.
- Email: firstname.lastname@example.org
Focus: Translating novel technologies from bench to bedside. My work ranges from in vivo to clinical studies and uses computational models to improve the efficacy and efficiency of technology development. Projects address clinical challenges in microsurgery, trauma, and muscle and soft tissue repair.
Plastic and Reconstructive Surgery
- Email: email@example.com
Focus: the mechanisms contributing to nerve regeneration following surgical reconstruction, specifically the reconstruction of long nerve defects.
- Email: firstname.lastname@example.org
Focus: Identifying and evaluating risk factors for rotator cuff disease, with an emphasis on genetic and occupational risk factors. Broad interest is in the interaction between genetic and non-genetic risk factors to influence musculoskeletal disease risk as a means of informing precision prevention approaches.