Membership Eligibility:
– Faculty appointment
– Active musculoskeletal researcher
– Intent to participate in MRC programs and/or use Core services

The MRC research community has more than 80 members (PIs) who have over 60 million dollars of annual research support (direct costs).

Showing: All results
Rebekah  Lawrence

Rebekah Lawrence

Physical Therapy

Focus: Understanding the modifiable biomechanical factors underlying shoulder pain and pathology leading to the development of evidence-based rehabilitation strategies.

Deborah  Lenschow

Deborah Lenschow

Rheumatology

Focus: the mechanism by which type I IFNs mediate their effector mechanisms through the study of various IFN stimulated genes.

Xiaowei Li

Xiaowei Li

Surgery

Focus: Developing biomaterial platforms for regenerative medicine, with specific interest in applications of biomaterials for angiogenesis and vascularization, stem cell engineering, and central nervous system and soft tissue regeneration.

Daniel  Link

Daniel Link

Internal Medicine

Focus: the mechanisms that regulate normal and leukemic hematopoiesis.

Gabriel  Mbalaviele

Gabriel Mbalaviele

Bone & Mineral Diseases

Focus: the role of the Leucine rich Repeat with a Pyrin domain 3 (NLRP3) inflammasome in bone.

Audrey  McAlinden

Audrey McAlinden

Orthopaedic Surgery

Focus: cartilage tissue, both articular and growth plate cartilage.

Sara  McBride-Gagyi

Sara McBride-Gagyi

Saint Louis University – Orthopaedic Surgery

Focus: the role of bone morphogenetic protein two (BMP2) on skeletal development and bone quality.

Helen McNeill

Helen McNeill

Developmental Biology

Focus: Regulation of growth and patterning. Our recent preliminary data in Drosophila has indicated that a poorly understood nuclear envelope protein, Nemp, is required for fertility and muscle stem cells. We are interested in determining if this is true for mammals. We have generated Nemp1 mutant mouse, and our recent preliminary data suggest a role in the muscle and skeleton. In addition, we study Fat4, a large cadherin. Mutations in Fat4 are associated with Van maldergem syndrome, which is characterized by a range of defects, including skeletal defects. We have generated targeted mutations in Fat4 in mice with CRISPR, and want to determine if there are defects in muscle and skeleton.

Isabel Menendez

Isabel Menendez

Orthopaedic Surgery

Focus: preclinical multimodal imaging technologies for biomarker discovery in orthopedic diseases

Gretchen  Meyer, PhD

Gretchen Meyer, PhD

Physical Therapy & Neurology

Focus: changes at the molecular and cellular level in skeletal muscle and how they affect muscle structure and function.

Kevin  Middleton

Kevin Middleton

University of Missouri – Pathology

Focus: the integrative biology and evolution of vertebrate “locomotor tissues” including not only bones and muscles but also feathers and wing membranes.

Bettina  Mittendorfer

Bettina Mittendorfer

Geriatrics

Focus: (1) fatty acid and lipoprotein metabolism leading to the discovery of significant sexual dimorphism in the regulation of lipid metabolism and (2) muscle protein metabolism with the goal to elucidate the influences of sex hormones, male/female genotype and fibre composition on the muscle anabolic response to feeding and exercise.

Camilo Molina

Camilo Molina

Neurological Surgery

Focus: Understanding the changes to paraspinal musculature in adult spinal deformity and degenerative diseases.

Daniel Moran

Daniel Moran

Biomedical Engineering

Focus: Brain-Computer Interfacing using intracalvarial electrodes.

Steven  Mumm

Steven Mumm

Bone & Mineral Diseases

Focus: the molecular genetics of metabolic bone diseases and skeletal dysplasias, with special emphasis on the patient population at the Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St. Louis.

Nicola  Napoli

Nicola Napoli

Bone & Mineral Diseases

Focus: the pharmacogenetics of osteoporosis, with emphasis on estrogen metabolic pathways, on the effects of bisphosphonates and other pharmacologic agents in osteoporosis, and on the effects of diabetes on bone health.

Jeffrey Nepple

Jeffrey Nepple

Orthopaedic Surgery

Focus: young adult hip disorders and pediatric sports medicine.

Colin G Nichols

Colin G Nichols

Cell Biology and Physiology

Focus: Role of ion channels in skeletal muscle fatigue and damage, and in skeletal deformation.

Regis O'Keefe, MD

Regis O’Keefe, MD

Orthopaedic Surgery

Focus: cartilage, bone repair, skeletal development, cancer and inflammatory diseases of bone.

David  Ornitz

David Ornitz

Developmental Biology

Focus: the mechanisms by which growth factors modulate skeletal fracture repair.

Russell  Pachynski

Russell Pachynski

Oncology

Focus: the impact of chemerin modulation in mouse models of prostate cancer.

Hua Pan

Hua Pan

Internal Medicine Division of Rheumatology

Focus: Design and deployment of practical and safe solutions for unmet medical needs. I have extensive research experiences in developing molecular diagnosis and nano-based drug/gene delivery strategies for inflammatory diseases, including autoimmune arthritis, cardiovascular diseases, kidney diseases, and cancer.

Cecilia  Pascual-Garrido

Cecilia Pascual-Garrido

Orthopaedic Surgery

Focus: cartilage regeneration, hip dysplasia, hip impingement, biomarkers, tissue engineering, stem cells, osteoarthritis.

Kamlesh Patel

Kamlesh Patel

Surgery

Focus: Investigation of muscle histology in patients with cleft lip and palate.

Debabrata Patra

Debabrata Patra

Developmental Biology

Focus: The importance of FGFR signaling to bone development and homeostasis using mouse as a model system.

Christine  Pham

Christine Pham

Rheumatology

Focus: role of proteases in immunity and autoimmunity.

Charlotte Phillips

Charlotte Phillips

Biochemistry and Child Health | Univ. of Missouri

Focus: The molecular/biochemical pathogenesis of osteogenesis imperfecta (OI) in mineralized and non-mineralized tissues, with a recent focus to develop alternative pharmacologic and therapeutic strategies to enhance muscle and bone quality and biomechanical integrity.

Ignacio Alberto  Portales Castillo

Ignacio Alberto Portales Castillo

Medicine

Focus: PTH signaling. PTH1R. Calcium and phosphorus homeostasis.

M. Farooq Rai

M. Farooq Rai

Orthopaedic Surgery

Focus: early molecular mechanisms that orchestrate changes in knee joint after injury and lead to the development of osteoarthritis.

Wilson Ray

Wilson Ray

Neurosurgery

Focus: Spinal cord injury, cervical myelopathy, electrical stimulation – peripheral nerve regeneration, electrical stimulation – bony fusion, peripheral neuroprosthetics

Alex Reiter

Alex Reiter

Biomedical Engineering (Saint Louis University)

Focus: Understanding the biomechanics of musculoskeletal soft tissue using methods ranging from preclinical models to wearable sensors in people.

Justin Sacks

Justin Sacks

Surgery, Division of Plastic and Reconstructive Surgery

Focus: Advancements in the fields of plastic and reconstructive surgery as whole, and specifically vascularized composite allotransplantation, tissue engineering, vascular perfusion assessment, breast reconstruction, and lymphedema. As such, the role of musculoskeletal tissue has a critical role in understanding the pathology, injury, or regeneration to achieve advances in these areas.

Rajan Sah

Rajan Sah

Cardiology

Focus: studying the intersection of ion channel mechanobiology and metabolism with a focus on cardiometabolic disease

Erica  Scheller

Erica Scheller

Bone & Mineral Diseases

Focus: synthesis of concepts from cell biology, physiology, and bioengineering to study the relationships between the nervous system and the skeleton. We have a directed interest in understanding how neural signals contribute to skeletal homeostasis, and how perturbations to this system contribute to bone loss, impaired healing, and changes in metabolism.

Lori  Setton

Lori Setton

Biomedical Engineering

Focus: imaging and fluid-based biomarkers of disease to characterize therapy benefits for pain and dysfunction.

Hua  Shen

Hua Shen

Orthopaedic Surgery

Focus: Development of effective treatments for tendon injuries and related disorders through multidisciplinary collaborations, which integrates the expertise and innovative technology in the field of translational tendon research, regenerative medicine, extracellular vesicle application, tissue engineering, and drug development.

Jie  Shen, PhD

Jie Shen, PhD

Orthopaedic Surgery

Focus: cartilage, bone repair, skeletal development, cancer and inflammatory diseases of bone.

Monica Shokeen

Monica Shokeen

Radiology

Focus:  molecularly targeted small molecule and multi-functional macromolecular bio-conjugates for nuclear and optical imaging of cancer and cardiovascular diseases. We are currently developing multi-modal imaging platforms for studying bone marrow related malignancies such as multiple myeloma.

Matthew Silva, PhD

Matthew Silva, PhD

Orthopaedic Surgery

Focus: Bone biomechanics and mechanobiology. Our lab focuses on two main questions.
1) How does mechanical loading stimulate bone formation?
2) How do bones heal after injury?

Allison Snyder-Warwick

Allison Snyder-Warwick

Surgery

Focus: facial reconstruction, facial nerve disorders, facial paralysis, facial clefts, cleft lip, cleft palate, ear reconstruction, microtia, reconstruction of obstetrical brachial plexus injuries, microsurgical procedures in children and adults.

Lilianna  Solnica-Krezel

Lilianna Solnica-Krezel

Developmental Biology

Focus:  the cellular and molecular genetic mechanisms underlying vertebrate gastrulation, a crucial period of embryogenesis during which the germ layers are formed and then shaped into the vertebrate body plan with organ rudiments.

Sheila  Stewart

Sheila Stewart

Cell Biology & Physiology

Focus:  the impact of aging on the tumor microenvironment.

Simon Tang, PhD

Simon Tang, PhD

Orthopaedic Surgery

Focus: (1) understanding the effect of disease mechanisms on the structure-function relationships of skeletal tissues and (2) developing of translatable therapeutic and regenerative strategies for these diseases. The investigation of these scientific questions includes the application of finite element analyses, multiscale tissue mechanics, the functional imaging of skeletal tissues, and development of nanostructures and nanomaterials for regenerative medicine with in vitro and in vivo biological systems.

Steven  Teitelbaum

Steven Teitelbaum

Pathology & Immunology

Focus: Osteoporosis

Linda  Van Dillen

Linda Van Dillen

Physical Therapy

Focus:  1) the sensory-motor factors underlying musculoskeletal pain conditions, and 2) how these factors interact with activity demand and psychsocial factors to increase risk for, or contribute to an existing musuloskeleletal pain condition.

Brian  Van Tine

Brian Van Tine

Oncology

Focus: the initiation, progression and relapse mechanisms of osteosarcoma.

Deborah Veis, MD, PhD

Deborah Veis, MD, PhD

Bone & Mineral Diseases

Focus: models of pathological bone loss including osteoporosis, breast cancer metastasis to bone, inflammatory arthritis and osteomyelitis

Rebecca  Wachs

Rebecca Wachs

University of Nebraska-Lincoln

Focus: establish robust animal models of chronic low back pain

Dong  Wang

Dong Wang

University of Nebraska-Lincoln

Focus: using various chemistry, pharmaceutical, and nanomedicine tools to address major problems in the diagnosis and treatment of musculoskeletal, inflammatory and craniofacial/dental diseases

Conrad  Weihl

Conrad Weihl

Neurology

Focus: the role of protein aggregation in hereditary myopathies and motor neuron disease