Directors

Focus: molecular steps critical for development and progression of such diseases related to osteoclasts.

Focus: the cellular and molecular basis of the bone remodeling process, and to devise mechanisms by which this balance can be modified.

Focus: the identification of common molecules that can modulate the activation of immune cells as well as osteoclasts.

Focus: cell and tissue engineering; development, degeneration, and aging; embryonic and adult tissue stem cells.

Focus: changes at the molecular and cellular level in skeletal muscle and how they affect muscle structure and function.

Focus: cartilage, bone repair, skeletal development, cancer and inflammatory diseases of bone.

Focus: synthesis of concepts from cell biology, physiology, and bioengineering to study the relationships between the nervous system and the skeleton. We have a directed interest in understanding how neural signals contribute to skeletal homeostasis, and how perturbations to this system contribute to bone loss, impaired healing, and changes in metabolism.

Focus: cartilage, bone repair, skeletal development, cancer and inflammatory diseases of bone.

Focus: Bone biomechanics and mechanobiology. Our lab focuses on two main questions.
1) How does mechanical loading stimulate bone formation?
2) How do bones heal after injury?

Focus: (1) understanding the effect of disease mechanisms on the structure-function relationships of skeletal tissues and (2) developing of translatable therapeutic and regenerative strategies for these diseases. The investigation of these scientific questions includes the application of finite element analyses, multiscale tissue mechanics, the functional imaging of skeletal tissues, and development of nanostructures and nanomaterials for regenerative medicine with in vitro and in vivo biological systems.

Focus: models of pathological bone loss including osteoporosis, breast cancer metastasis to bone, inflammatory arthritis and osteomyelitis